Addison’s-Like Disease (Hypoadrenocorticism)

Causes of Hypoadrenocorticism The causes of Addison’s-like disease are listed in Part A. Idiopathic primary hypoadrenocorticism is reportedly bilateral, and apparently has an immune-mediated basis in animals, as in humans. Animals with this disease sometimes exhibit additional endocrinopathies (e.g., hypothyroidism, diabetes mellitus, or hypogonadism). latrogenic primary hypoadrenocorticism may follow administration of the adrenocorticolytic drug mitotane (o,p -DDD, Ortho para DDD, Lysodren) for the treatment of Cushing’s-like syndrome (Ch. 25).