ABSTRACT
Potential Physicochemical Degradation Sites...................................................8 1.4 Using Computation to Advance Our Understanding of Physicochemical
Degradation of Biopharmaceuticals ............................................................... 18 1.5 Computational Assessments of Adverse Immunogenicity for Biologic
Candidates ...................................................................................................... 21 1.6 Linking Physicochemical Degradation with Safety of Biologics:
Aggregation-Immunogenicity Coupling ........................................................24 1.7 Estimating High-Concentration-Solution Behavior of Biological
Candidates via Computation ...........................................................................25 1.8 Conclusions and Future Directions .................................................................29 Acknowledgments ....................................................................................................30 Summary ..................................................................................................................30 References ................................................................................................................30
