ABSTRACT
This chapter describes the requirements of powder blends for successful tableting. It describes the relationship between tablet disintegration, dissolution, and absorption. All tablets should have identical size, shape, thickness, color, and surface markings. The general appearance of the tablet allows monitoring a lot-to-lot and tablet-to-tablet uniformity. The drug is released from the dosage form by physical disruption associated with chewing and dissolution in the fluids of the oral cavity, and the presence of an effervescent material. Disintegration of tablets is evaluated to ensure that the tablet dissolves or breaks apart into smaller particles or granules on contact with water under agitation. Glidants are added to tablet formulations to improve the flow properties of the granulations during transfer operations, such as from the hopper to the roller compactor or tablet press. Granulating fluids are liquids that are used for wet granulation.
