ABSTRACT

Macronutrient deciency during the prenatal and early postnatal period is related to poorer cognitive and motor development in both animal models and humans, and these effects can last through adolescence and adulthood. Overall, children and adolescents who suffer severe malnutrition in early life demonstrate IQ decits and poorer school performance compared to individuals who are not malnourished, especially for those experiencing chronic life stress (Grantham-McGregor 1995). Supplementation trials generally indicate improvements in outcomes depending on the timing of the intervention; specically, prenatal and early postnatal (aged 0-3 years) interventions have the

2.1 Introduction .................................................................................................... 21 2.2 Biological Mechanisms of Macronutrient Deprivation ..................................22