ABSTRACT
Magnetic nano-and microsized particles can be used for various biomedical applications for example, cell separation, immobilization of enzymes and viruses, detoxification of biological liquids, magnetic drug targeting und others [1-5], the most widespread being neutron capture therapy (NCT) when they become compounds with 10B (BNCT). There are two boron containing compounds, one being L-borophenilalanin (L-BPA) used in clinical practice [6]. The aim of the research is to work out new methods to modify the surface of different chemical content microsized ferrocomposites particles with biocompatible materials for the immobilization of biologically active compounds and to evaluate the possibility to use them as sorbents for extracorporal detoxification of patient’s blood and conserve donor blood after purification from free hemoglobin and barbiturates by the method of magnetic separation and as carriers for magnetically guided target delivery of L-BPA at BNCT.
