ABSTRACT
The method of electron paramagnetic resonance was used to study the influence of mexidol (2-ethyl-6-methyl-3-hydropyridine succinate) on the heart and liver tissues of experimental animals. It has been shown that mexidol protects the iron-sulfur centers of the respiratory chain of the heart mitochondria in the composition of integral animal tissues from oxidizing damage and increases nitric oxide formation in cells and the degree of hemoglobin oxygenation. It has been suggested that the maintenance of the mitochondrial iron-sulfur centers in the reduced working state (under oxidation conditions) is most likely to be due to the presence of succinate, a metabolic component of the cycle of tricarboxylicacids, in the composition of mexidol.
