ABSTRACT
This chapter presents a mathematical approach to describe peritoneal transport and some practical implications of the modeling for peritoneal chemotherapy. It describes the spatially distributed mathematical model of fluid and solute transport through the peritoneal tissue and formulas for the estimation of the solute penetration depth derived from the model. The chapter discusses a version of this model that is applied for a description of the transport in solid tumor. It analyses the difference between transport parameters in the normal and neoplastic tissue and its consequences for the fluid and solute peritoneal transport. The application of distributed models in intraperitoneal therapies was initiated in the early 1980s. The accessibility from the peritoneal cavity, distance for therapeutic agent to reach the target, therapeutic agent size, and transport characteristics of both target and drug determine the efficiency and utility of the intraperitoneal therapy. The process of intraperitoneal drug delivery, especially for anticancer therapies, was also described using the distributed approach.
