ABSTRACT
This presentation is based on experiments performed in this laboratory over the last couple of years. Monoarthritis, induced by intraplantar injection of Freund's complete adjuvant in rats, served as our model of inflammatory pain, and the paw pressure test of Randall-Sellito was used to measure nociception. Pharmacological, biochemical, histochemical and immunological methods were used to analyze the mechanisms underlying the antinociceptive effects of exogeneously applied and/or endogeneously released opioids.
EFFECTS OF EXOGENOUSLY APPLIED OPIOIDS
