ABSTRACT
In this chapter, contrast-enhanced ultrasound (CEUS) and ultrasound contrast agent microbubble adjustments for drug delivery including sonoporation are described. Although hundreds of papers have been published on this subject, we will just brie y touch upon the topic using a physics and engineering approach.
Microbubbles that are used for ultrasonic imaging purposes are termed ultrasound contrast agents. After intravascular injection of an agent into the circulation, microbubbles pass the site of interest that is being examined by the clinician. Upon sonication, the microbubbles generate a microbubble-characteristic response, which is detected by the ultrasound scanner used. The resulting sonographic image can then be interpreted by the clinician.
