ABSTRACT
Synthetic oligonucleotides offer interesting prospects for the control of gene expression through specific interactions with RNA (antisense oligonucleotides, ribozymes), DNA (triple helix-forming oligonucleotides) or even proteins (decoy oligonucleotides, aptamers). These strategies, and in particular ribozymes and antisense ON, have been the object of numerous studies in various in vitro and in vivo (including several human clinical trials) biological models.
