ABSTRACT
High Throughput Screening (HTS) has become a common tool of drug discovery. The general strategy is to screen a vast collection of samples in the hopes of finding compounds with moderate activity from which to develop new leads. In the past the size of the sample collection was moderate, but this has changed with the increased availability of natural product libraries and even more so with the increased use of synthetic combinatorial (combi-chem) libraries. With increased sample size the efficiency of screening has become central to the success of the process.
