ABSTRACT

Recently, the emergence of high-throughput screening (HTS) significantly increased the need for new organic compounds suitable for biological testing. Approaches like solidphase synthesis of mixtures of organic compounds, the Affymax VLSIP technology, the double combinatorial approach or the Diversomer™ technology (see chapter 8 in this section), were introduced (1) among others, to meet this need. The increased productivity of combinatorial chemistry approaches is justified by the fact that classical organic chemistry, today still the main source of the organic samples that undergo new drug candidate (ndc) testing, involves synthetic procedures which are difficult to plan or control, have low productivity and are difficult to automate compared to bulk production.