ABSTRACT
We have attempted to write this chapter as an instructional text based on our general approach for analyzing glycoproteins. We have also tried to highlight some of the typical problems encountered, but rarely published, in the mass spectrometric analysis of these samples. Because complete books could be written on the structural characterization of glycoproteins, we have limited our fo-
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cus to mammalian glycoproteins and their "typical" carbohydrate side chains. We therefore have not attempted to include every situation that could be encountered when analyzing glycoproteins, nor every mass spectrometric approach that has been used for their analysis.
