ABSTRACT
Although several impressive linear solid-phase syntheses of proteins have been achieved [I], methodological improvements are continually allowing larger peptides to be routinely considered. However, 'homogeneous large target molecules are probably best produced chemically by convergent strategies that rely on the union of peptide segments. A key advantage of this approach is that such segments can be purified and characterized, providing a series of analytical data on the nature of the material being synthesized and facilitating the purification of the final product. Most modern convergent peptide synthesis strategies are based to some extent on the use of solidphase methods because of the advantages in economics and rapidity that these present. Several reviews [2-4] of such strategies have already appeared; here we present an updated report on practical, useful methods.
