ABSTRACT
Drug design is a complex process and requires multidisciplinary approaches from concept generation to lead optimization and to eventually putting a drug on the market. As this subject is so vast, it is impossible to draw even an abbreviated picture of the whole topic in one chapter. Instead, the intention of the author is to present the importance of the one-dimensional and two-dimensional quantitative structure-activity relationship (QSAR) paradigm in drug design in as simplistic a way as possible to a readership not sufficiently familiar with the field. Three-dimensional QSAR is covered in Chapter 4.
