ABSTRACT
Combinatorial chemistry has expanded rapidly in the last decade, in both the development and the application of novel chemistry for the synthesis of com pound libraries for lead discovery and in lead optimization in the fields of biotech nology, catalysts, new materials, agriculture, and pharmaceuticals. To achieve high productivity in combinatorial compound library synthesis, both parallel syn thesis and the split-and-pool technique have evolved and gained significant accep tance. Parallel synthesis can produce discrete compounds in multimilligram quan tities. However, only a limited number of compounds can be synthesized per unit time and per reaction. The split-and-pool technique can address this problem of parallel synthesis; however, it yields mixtures that need to be deconvoluted. A hybrid technique referred to as “ directed sorting” addresses these disadvantages of parallel and split-and-pool synthesis.
