ABSTRACT
Fluorine-19 nuclear magnetic resonance (19F NMR) spectroscopy offers an excel lent tool for the investigation of combinatorial chemistry processes, from the optimization of reaction conditions via quantitative techniques and characteriza tion of reaction products to the determination of the reaction kinetics including the cleavage of library compounds from solid supports. Nuclear magnetic resonance spectroscopy in general is an extremely information-rich technique for structural investigation, and 19F NMR spectroscopy in particular offers advantages over both carbon and proton NMR specific to combinatorial chemistry applications. Most resins upon which libraries are synthesized do not contain fluorine, so there is no background signal due to the solid support.
