Breadcrumbs Section. Click here to navigate to respective pages.
Chapter
Chapter
baby, was found in Switzerland. This antibody was used in Bern to screen donors. Four new JAL+ propositi were found in 90,000 donors, all four were French speaking. The frequency of the antigen was calculated to be 0.004% overall but 0.06% in French-speaking Swiss [36]. The families of the antibody maker and the 4 JAL+ donors were studied. The results proved that JAL was part of the Rh system or encoded by a very closely linked locus [36]. JAL in Whites is associated with depression of C antigen but in Blacks JAL is probably associated with a depressed c [35]. We wondered if there were any difference between the JAL antigen associated with depressed C and that associated with depressed c. Titrations of two anti-JAL with JAL+ cells of weak C and weak c phenotypes showed that there was no significant difference between the two samples [35]. It is noteworthy that the anti-JAL of Mrs S Allen was stimulated by pregnancy and her husband was cDe JAL+ but J Pas’s anti-JAL, also stimulated by pregnancy, was made in response to a depressed C JAL+ complex. So the expression of JAL does not depend on the C or c with which it is associated. Both these anti-JAL were responsible for haemolytic disease of the newborn [35]. Low incidence antigen FPTT (RH50) In contrast to JAL, the FPTT+ sample was more easily detected by the polyclonal anti-C (the ones with incomplete anti-D) than by commercial anti-C (Table III). FPTT presents a much more difficult problem than JAL. Adsorption/elution tests are needed to identify the antigen. Family studies showed that FPTT is associated with at least 5 different depressed antigenic complexes (Table IV). One complex, that of propositus 1 [37], had depressed C and e antigens, the complex of propositus 2 [37] had depressed C antigen and depressed e antigen
DOI link for baby, was found in Switzerland. This antibody was used in Bern to screen donors. Four new JAL+ propositi were found in 90,000 donors, all four were French speaking. The frequency of the antigen was calculated to be 0.004% overall but 0.06% in French-speaking Swiss [36]. The families of the antibody maker and the 4 JAL+ donors were studied. The results proved that JAL was part of the Rh system or encoded by a very closely linked locus [36]. JAL in Whites is associated with depression of C antigen but in Blacks JAL is probably associated with a depressed c [35]. We wondered if there were any difference between the JAL antigen associated with depressed C and that associated with depressed c. Titrations of two anti-JAL with JAL+ cells of weak C and weak c phenotypes showed that there was no significant difference between the two samples [35]. It is noteworthy that the anti-JAL of Mrs S Allen was stimulated by pregnancy and her husband was cDe JAL+ but J Pas’s anti-JAL, also stimulated by pregnancy, was made in response to a depressed C JAL+ complex. So the expression of JAL does not depend on the C or c with which it is associated. Both these anti-JAL were responsible for haemolytic disease of the newborn [35]. Low incidence antigen FPTT (RH50) In contrast to JAL, the FPTT+ sample was more easily detected by the polyclonal anti-C (the ones with incomplete anti-D) than by commercial anti-C (Table III). FPTT presents a much more difficult problem than JAL. Adsorption/elution tests are needed to identify the antigen. Family studies showed that FPTT is associated with at least 5 different depressed antigenic complexes (Table IV). One complex, that of propositus 1 [37], had depressed C and e antigens, the complex of propositus 2 [37] had depressed C antigen and depressed e antigen
baby, was found in Switzerland. This antibody was used in Bern to screen donors. Four new JAL+ propositi were found in 90,000 donors, all four were French speaking. The frequency of the antigen was calculated to be 0.004% overall but 0.06% in French-speaking Swiss [36]. The families of the antibody maker and the 4 JAL+ donors were studied. The results proved that JAL was part of the Rh system or encoded by a very closely linked locus [36]. JAL in Whites is associated with depression of C antigen but in Blacks JAL is probably associated with a depressed c [35]. We wondered if there were any difference between the JAL antigen associated with depressed C and that associated with depressed c. Titrations of two anti-JAL with JAL+ cells of weak C and weak c phenotypes showed that there was no significant difference between the two samples [35]. It is noteworthy that the anti-JAL of Mrs S Allen was stimulated by pregnancy and her husband was cDe JAL+ but J Pas’s anti-JAL, also stimulated by pregnancy, was made in response to a depressed C JAL+ complex. So the expression of JAL does not depend on the C or c with which it is associated. Both these anti-JAL were responsible for haemolytic disease of the newborn [35]. Low incidence antigen FPTT (RH50) In contrast to JAL, the FPTT+ sample was more easily detected by the polyclonal anti-C (the ones with incomplete anti-D) than by commercial anti-C (Table III). FPTT presents a much more difficult problem than JAL. Adsorption/elution tests are needed to identify the antigen. Family studies showed that FPTT is associated with at least 5 different depressed antigenic complexes (Table IV). One complex, that of propositus 1 [37], had depressed C and e antigens, the complex of propositus 2 [37] had depressed C antigen and depressed e antigen
ABSTRACT