ABSTRACT
Research on biological NO is extremely active. In 1997 alone there were over 3000 papers published studying inhibitors of nitric oxide synthase (NOS) and about 100 of these dealt with new agent synthesis. To the medicinal chemist interested in struc ture-activity correlations, in chemical mechanisms of inhibition, and in models of drug-binding site interaction, the field of NOS inhibition stands now where the benzodiazepine development stood in the early 1970s.
