ABSTRACT
In renal disease, substances that would otherwise be excreted through the kidney accumulate in the blood. The patient will develop uremia and die unless the blood can be cleared of these substances by artificial dialysis or filtration. Although the principal compounds responsible for uremia, called uremic toxins, are still to be defmed, compounds such as urea, uric acid, creatinine, and methylguanidine are detected as marker substances for uremia. 242 In patients with renal disorders, adequate control of the variation of electrolyte concentration in body fluids is indispensable. Simultaneous determination of these uremic toxins and electrolytes is extremely difficult to attain.
