THE PROCESSING OF THE AMYLOID-PRECURSOR-PROTEIN (APP) IN PRESENILIN-1 DEFICIENT NEURONS

A distinguishing feature of Alzheimer’s disease (AD) is the deposition of amyloid plaques in the brain, which arise by abnormal accumulation of βA4 peptide (Selkoe, 1991). The 39-43-residue βA4Amyloid peptide, the main component of the amyloid plaque in the brain of Alzheimer’s disease patients is generated from amyloid precursor protein (APP) by proteolytical processing (Haass and Selkoe, 1993).