ABSTRACT
FIBROBIAST GROWTH FACTORS AND THEIR RECEPTORS Fibroblast growth factors (FGFs) comprise a growing group of structurally similar polypeptide mitogens which currently includes 18 different members. Besides the initially discovered acidic FGF (aFGF, FGF-1) (Jaye et al., 1986) and basic FGF (bFGF, FGF-2) (Abraham et al., 1986), the family also includes the products of the proto-oncogenes int-2 (FGF-3), (Moore et al., 1986), hst (FGF-4) (Delli-Bovi et al., 1987), FGF-5 (Zhan et al., 1988), and FGF-6 (Maries et al., 1989), as well keratinocyte growth factor (KGF, FGF-7) (Rubin et al., 1989), androgen-induced growth factor (AIGF, FGF-8) (Tanaka et al., 1992), gliaactivating factor (GAF, FGF-9) (Miyamoto et al., 1993), four fibroblast growth factor homologous factors (FHFs, FGFs 11-14) (Smallwood et al., 1996), FGF-15 (McWhirter et al., 1997), FGF-16 (Miyake et al., 1998), FGF-17 (Hoshikawa et al., 1998), and FGF-18 (Ohbayashi et al., 1998).
