ABSTRACT

The demonstration in the 1960s and 70s (Divac 1968; Divac, Rosvold and Scwarcbart, 1967; Rosvold 1972) that lesions to restricted striatal areas result in the same kind of behavioural deficits as lesions of the anatomically-associated frontocortical areas, has been seminal to the promulgation of the idea that the frontal cortex and the striatum operate in tandem to produce behavioural output. This idea has received a powerful impetus from the notion, pioneered by DeLong and Georgopoulos (1981) that anatomically and functionally

associated regions of the striatum and the frontal cortex are linked within several basal ganglia-thalamocortical circuits.