ABSTRACT
A 62-year-old woman was hospitalized approximately six months after starting amiodarone (300 mg once daily). Symptoms upon admission included tachycardia (100 bpm), irregular heart rate, generalized weakness, nausea, vomiting, and headache. Other chronic concurrent medications included farnotidine (40 mg daily) and lorazepam (1 mg daily). Abnormal laboratory values included reduced serum sodium levels (121 mmol/L) and serum osmolality (243 rnmollkg H20) with increased urine sodium levels (141 mmol/L). Other laboratory values were within normal ranges including calcium, potassium, serum creatinine, liver enzyme levels, and thyroid function. Prajmalium bitartrate was substituted and serum sodium levels gradually increased and general weakness reversed within five days after amiodarone withdrawal. Within two weeks, serum sodium levels normalized (143 mmol/L) and hyponatremia did not recur.
