ABSTRACT

Immunological tests for diagonizing tumors were based upon a coagula­ tion test for immunocomplex (IC). Coagulating I & C diminishes the specificity of these tests. Ishii et al. (OTSUKA PHARMACEUTICAL CO., LTD. (124)) seek to overcome this drawback by testing for com­ plement-binding ICs wherein the consistuent antigens are tumor associ­ ated antigens (tumor markers) such as BFP (basic fetoprotein), AFP (a-fetoprotein) TAG (tumor associated glycolinkage). Such an IC as bound to an insolubilized anti-complement, can be specifically bound to a labeled substance or such an IC alone can be specifically insolubilized and labeled.