ABSTRACT
This chapter will consider the molecular mechanisms and the consequences of interindividual variability of human N-acetyltransferase (E.C. 2.3.1.5). The two known isoforms of the human enzyme (NAT1 and NAT2) catalyze transfer of an acetyl group, primarily from AcCoA, to the amino nitrogen of an acceptor amine producing an acetamide. Certain hydrazines can also serve as substrates for acetylation and the acetylation of the antitubercular hydrazine isoniazid has been instrumental in the discovery and understanding of variability in human acetylation activity.
