ABSTRACT
Microspheres are defined as homogeneous, monolithic particles in the size range of about 0.1-1000 fim and are widely used as drug carriers for controlled release. These systems have significant importance in biomedical applications. Administration of drugs in the form of mi crospheres usually improves the treatment by providing the localization of the active substance at the site of action and by prolonging release of drugs. Furthermore, sensitive drugs such as peptides and proteins may be protected against chemical and enzymatic degradation when en trapped in microspheres (10,11). In drug delivery applications, poly(DL-lactide-co-glycolide) microspheres are being considered as the pharmaceutical products of the future.
