ABSTRACT
Fresh, raw milk includes the group of proteins that remain soluble in "milk serum." These proteins can be preserved in their native form if extracted carefully from their natural source.
In 1981 it was discovered that normal mice fed a milk serum protein concentrate (specially prepared under mild nondenaturing conditions) exhibited a marked increase in the humoral immune response to a T helper cell-dependent antigen (1). In the following years, numerous experiments confirmed the consistency of this phenomenon (2-10). Over a period of 12 years and based on these findings a humanized native milk serum protein isolate (HNMPI) named IMMUNOCAL™ was developed (Immunotec Research Corporation Ltd., Montreal, Quebec, Canada).
