ABSTRACT

Most databases are built from sequences of genes, genomes, and structures of proteins. However, less is known about which macromolecules-nucleic acids, proteins, lipids, and carbohydrates-interact how and when to give structure and function to a cell, be they single-cell organisms like bacteria and yeasts, or multicellular organisms like plants and animals. Furthermore, because mRNAs are the molecular intermediate during protein biosynthesis,

transcript levels are often interpreted regarding their biological relevance as if they correlate with actual protein levels.