ABSTRACT

DNA is the central object of research in recent biochemistry or molecular biology. New and apparently limitless areas of research and fields of applications concerning cell manipulations are continuously discovered. The frontiers of the biosciences have been pushed forward with an incredible speed for more than 40 years now. How can organic chemists contribute? How can synthetic DNA derivatives and analogs become of value in the treatment of diseases and genetic malfunction? How can DNA be used in synkinesis? There are several possibilities, five of which are mentioned here:

1. Nucleosides connected by amide instead of phosphodiester bonds may yield stable antagonists to DNA as well as work as direct links between DNA and proteins.