ABSTRACT

D.ConditionsinWhichlmmunoinsufficiencyMayOccur 1.Pregnancy Thereisconflictingevidenceofreducedimmuneresponsivenessduringpregnancy(159)to antigensofpaternalorigininheritedbythefetus.However,atleastonecaseoffatalTI-GVHD hasbeenreportedinapregnantwomanthoughttohavebeenimmunocompetentpriorto pregnancy(70).Insuchinstances,therarechanceofHLAhaplotypehomozygositycontributing tothisoccurrencecanbeincreasedwiththeuseofdonorswithclosebloodrelationshipsorin certainethnicgroups.