ABSTRACT
AsemphasizedinanexcellentreviewbyPauza(160),harboringofHIVinmonocytesvia persistentnoncytolyticinfectionmayexplaintheeventualinabilityoftheimmuneresponseto controlHIVinfection.Becauseviralreplicationisrestrictedininfectedmonocytes,they probablydonotdisplaysignificantlevelsofHIVantigensontheirsurface.Thesecellsarethus refractorytotheHIV-specificcytolyticactivitiesofcytotoxicTcellsandcellsmediatingADCC. Infectedmonocytesthus,inalllikelihood,serveasamajorreservoirofHIV,leadingto persistent,ongoinginfectioneveninthepresenceofarobustHIV-specificimmuneresponse.
H.ImmuneSystemActivationandHIVInfection
