ABSTRACT
NCI CARC TRS 196 NIH PUB NO 80-1752 UNDER THE CONDITIONS OF THIS BIOASSAY, CINNAMYL ANTHRANILATE WAS CARCINOGENIC FOR MALE AND REMALE B6C3F1 MICE, INDUCING AN INCREASED OF HEPATOCELLULAR CARCINOMAS OR ADENOMAS. THE TEST CHEMICAL WAS ALSO CARCINOGENIC FOR MALE F344 RATS, INDUCING A LOW INCIDENCE OF ACINAR-CELL CARCINOMAS OR ADENOMAS OF THE PANCREAS AND ADENOCARCINOMAS OR ADENOMAS OF THE RENAL CORTEX. CINNAMYL ANTHRANILATE WAS NOT CARCINOGENIC FOR REMALE F344 RATS.
IARC MONOGRAH 16 1978 IN THE ONLY AVAILABLE STUDY, CINNAMYL ANTHRANILATE INCREASED THE INCIDENCE OF LUNG TUMORS IN MICE FOLLOWING INTRAPERITONEAL INJECTION. THESE DATA ARE INSUFFICIENT FOR EVALUATION OF THE CARCINOGENICITY OF THIS COMPOUND.
