ABSTRACT
NCI CARC TRS 104 DHEW PUB NO NIH 78-1354 NO TUMORS OCCURRED IN DOSED RATS OR MICE OF EITHER SEX AT INCIDENCES THAT WERE SIGNIFICANTLY HIGHER THAN THOSE IN CORRESPONDING CONTROLS. MALE AND FEMALE RATS AND FEMALE MICE MAY HAVE BEEN ABLE TO TOLERATE HIGHER DOSES. IT IS CONCLUDED THAT UNDER THE CONDITIONS OF THIS BIOASSAY, ANILAZINE WAS NOT CARCINOGENIC FOR EITHER FISCHER 344 RATS OR B6C3Fl MICE (FEEDING STUDY). AGRICULTURAL FUMIGANT
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IARC MONOGRAPH 4 1974 THERE IS NO ADEQUATE DATA TO INDICATE THAT ANILINE IS CARCINOGENIC IN EXPERIMENTAL ANIMALS. AT THE PRESENT TIME, THE WEIGHT OF EPIDEMIOLOGICAL EVIDENCE SUGGESTS THAT ANILINE IS NOT A CARCINOGEN FOR THE HUMAN BLADDER.
