ABSTRACT
IARC MONOGRAPH 4 1974 CMME IS ALMOST INVARIABLY CONTAMINATED BY BCME, AND THE LA TIER MAY BE RESPONSffiLE FOR AT LEAST PART OF THE OBSERVED CARCINOGENIC ACTIVITY. SUCH CONTAMINATED CMME HAS BEEN FOUND TO BE CARCINOGENIC ON SUBCUTANEOUS INJECTION IN THE MOUSE AND POSSffiL Y TO BE AN INITIATOR FOR SKIN TUMORS. INHALATION IN MICE AND SUBCUTANEOUS INJECTION PRODUCED EQUIVOCAL EVIDENCE OF CARCINOGENIC ACTIVITY. ONE STUDY BASED ON 4 CASES OF OAT CELL LUNG CANCER AMONG 111 WORKERS EXPOSED TO CMME, FOLLOWED FOR 5 YEARS, SUGGESTS AN INCREASED RISK OF LUNG CANCER.
