ABSTRACT
IARC MONOGRAPH 17 1978 N-NITROSONORNICOTINE IS CARCINOGENIC IN RATS, MICE, AND SYRIAN GOLDEN HAMSTERS. FOLLOWING ITS ORAL ADMINISTRATION TO RATS, IT PRODUCES CARCINOMAS OF THE UPPER DIGESTIVE TRACT, MAINLY THE ESOPHAGUS, AND OF THE NASAL CAVITIES. IN HAMSTERS, ITS SUBCUTANEOUS INJECTION PRODUCES MAINLY TRACHEAL TUMORS. IN MICE, ITS INTRAPERITONEAL INJECTION PRODUCES LUNG TUMORS. IN A 1979 SUPPLEMENT, IARC DETERMINED THAT THERE IS SUFFICIENT EVIDENCE FOR THE CARCINOGENICITY OF N-NITROSONORNICOTINE IN ANIMALS.
