ABSTRACT
DRAFT NTP TR 349 NIH PUB. 89-2804 MAR 89 UNDER 2 YEAR FEED STUDIES CLEAR EVIDENCE OF CARCINOGENIC ACTIVITY FOR MALE B6C3Fl MICE FED DIETS CONTAINING TECHNICAL-GRADE PENTACHLOROPHENOL, SHOWN BY ADRENAL MEDULLARY AND HEPATOCELLULAR NEOPLASMS. SOME EVIDENCE OF CARCINOGENIC ACTIVITY FOR FEMALE B6C3Fl MICE EXPOSED TO TECHNICAL-GRADE SHOWN BY HEMANGIOSARCOMAS AND HEPATOCELLULAR NEOPLASMS. CLEAR EVIDENCE OF CARCINOGENIC ACTIVITY FOR MALE B6C3Fl MICE EXPOSED TO PENTACHLOROPHENOL, EC-7 SHOWN BY ADRENAL MEDULLARY AND HEPATOCELLULAR NEOPLASMS. CLEAR EVIDENCE OF CARCINOGENIC ACTIVITY FOR FEMALE B6C3Fl MICE EXPOSED TO PENTACHLOROPHENOL, EC-7, SHOWN BY ADRENAL MEDULLARY AND HEPATOCELLULAR NEOPLASMAS AND HEMANGIOSARCOMAS.
EPA RCRA HEALTH AND ENV. EFFECTS PROFILE OCT 80 PENTACHLOROPHENOL HAS SHOWN NO EVIDENCE OF CARCINOGENICITY. EVIDENCE FOR MUTAGENICITY IS EQUIVOCAL. PENTACHLOROPHENOL IS TERATOGENIC IN EXPERIMENTAL ANIMALS AT LEVELS WHICH PRODUCE MATERNAL OR FETAL TOXICITY.
