ABSTRACT
NTP TECH REPORT TR 322 JAN 87 UNDER CONDITIONS OF THESE 2-YEAR STUDIES, NO EVIDENCE OF CARCINOGENICITY FOR MALE OR FEMALE F344/N RATS GIVEN 620 OR 1250 PPM IN FEED, OR FOR MALE OR FEMALE B6C3Fl MICE GIVEN 1250 OR 2500 PPM IN FEED. SURVIVAL OF HIGH DOSE RATE MALE RATS GREATER THAN IN CONTROLS AND INCIDENCES OF MONONUCLEAR CELL LEUKEMIA AND PHEOCHROMOCYTOMAS LOWER IN DOSED THAN IN CONTROL MALE RATS. INFLAMMATION MORE FREQUENTLY SEEN IN LIVER AND PROSTATE GLAND OF DOSED MALE RATS THAN IN CONTROLS. NASAL DECONGESTANT AND OPHTHALMIC APPLICATIONS
60-12-8 CHEM NAME : *** 2-PHENYLETHANOL (2-PE) REPORT 01
REPT'D USE
EPA CHIP MAY 85 PREGNANT RATS GIVEN 4.2 MG/KG 2-PHENYLETHANOL BY GAVAGE ON DAYS 6-15 OF GESTATION, SHOWED TERATOGENIC EFFECTS. 2-PE GAVE NEGATIVE RESULTS IN DNA REPAIR ASSAY IN E. COLI; GENE CONVERSION ASSAY INS. TYPHIMURIUM TA98, TA1535 AND TA1537; MITOCHONDRIAL DNA ASSAY IN S. CERVISIAE AND SISTER CHROMATID ASSAY IN HUMAN LYMPHOCYTES. FOOD FLAVORING AGENT AND COSMETIC AND DETERGENT FRAGRANCE
REPORT 01
CAS NO
NIOSH CRITERIA DOCUMENT JUN 78 PGE HAS SHOWN MUTAGENIC ACTIVITY IN THE SALMONELLA ASSAY, BUT IT PRODUCED NO DOMINANT LETHAL OR TERATOGENIC EFFECTS IN MICE EXPOSED TO 11.5 PPM FOR 12-19 DAYS. INCONCLUSIVE EVIDENCE TO TESTICULAR DEGENERATION WAS REPORTED IN SOME RATS EXPOSED TO 1.75-11.2 PPM PGE, NIOSH RECOMMENDS A LIMIT OF 1 PPM FOR PGE, MEASURED AS A 15 MIN CEILING CONCENTRATION, TO PREVENT SKIN AND RESPIRATORY TRACT IRRITATION.
