ABSTRACT
Throughout much of sub Saharan Africa children are exposed to the risk of malaria infection from birth. The degree of exposure that can maintain stable malaria endemicity varies in cmde terms over about three log orders , from around one infected bite a year [0 greater than a thousand (Snow and Marsh, 1 995) . However although the pattern of clinical syndromes varies with transmission, all parts of the clinical spectrum are seen to some degree in all areas where there is stable endemicity. I will thus first describe the overall picture of malarial disease before briefly discussing the influence of variations in transmission on the clinical pattern.
