ABSTRACT
Osteosarcoma, characterized by a high malignant and metastatic potential, principally affects children and adolescents [1]. Progression of disease is inexorable and response to therapy can be unrewarding: fewer than 50% of patients live beyond 10 years, and there are no reliable predictors to guide the choice or intensity of therapy [1,2]. Several improvements in understanding the molecular pathology of metastatic osteosarcoma have been achieved in the last several years [1]. However, the molecular mecha-
nisms underlying this malignancy are still largely unknown. For this reason, elucidating the signaling pathways involved in the metastatic cascade has become a key goal for developing novel effective therapeutics aimed at reducing osteosarcoma mortality rates.
