ABSTRACT
Colorectal cancer (CRC) is the 3rd most common cancer in Korea and is becoming more common in Asia and Western countries [1]. As new anti-cancer agents and new technology for local treatment have been developed, the survival rates of patients with CRC have been increasing, even for patients with stage IV cancer. However, distant organ metastasis eventually develops in stage IV cancer, and leads to fatal organ failure. To improve survival outcomes, it is important to control cancer invasion and metastasis, but the mechanisms by which CRC becomes metastasis are not yet known.
