ABSTRACT
Nonalcoholic fatty liver (NAFL) had long been believed to be a nonprogressive disease called simple steatosis. However, several researchers have more recently reported progressive NAFL in patients with diabetes, called diabetic cirrhosis (Itoh et al. 1979). Ludwig et al. (1980) have named
Abstract .......................................................................................................................................... 349 25.1 Introduction .......................................................................................................................... 349 25.2 Pathogenesis of NAFLD ....................................................................................................... 350
25.2.1 Disease-Specic Gene Polymorphism ..................................................................... 350 25.2.2 Obesity and Insulin Resistance ................................................................................. 351 25.2.3 Oxidative Stress ........................................................................................................ 352 25.2.4 Endoplasmic Reticulum Stress and Autophagy ........................................................ 352 25.2.5 Inammatory Reactions ........................................................................................... 352
25.3 Oxidative Stress as Main NASH Progression-Related Factor .............................................. 353 25.4 Pathogenesis-Targeted Treatment of NAFLD ...................................................................... 354
25.4.1 Standard Oxidative Stress-Targeted Treatment ....................................................... 355 25.4.2 Antidiabetic Insulin Resistance Treatment ............................................................... 355 25.4.3 Other Candidate Treatments ..................................................................................... 356 25.4.4 Newly Emerging Antioxidant Candidate .................................................................. 356
25.5 Conclusion ............................................................................................................................ 357 References ...................................................................................................................................... 357
nonalcoholic steatohepatitis (NASH) from their experience with 20 cases. At rst, the disease entity was not widely accepted; however, lifestyle changes have forced clinicians and patients to increasingly accept NAFL as a life-threatening disease from Western to Eastern countries.
