ABSTRACT

The first 1,000 days, from conception to two years of age, is a critical period of growth and development. Exposures to dietary, environmental, hormonal, and other stressors during this window have been associated with an increased risk of poor health outcomes, some of which are irreversible. The book addresses this crucial interval of early life across biological disciplines, linking concepts related to all biological fields to outcomes during the first 1,000 days (e.g. fetal growth and pregnancy outcomes) and beyond (e.g. gut microbiome and cardiovascular disease later in life). The strength of this book lies in its cross-disciplinary nature.

section I|2 pages

Introduction

chapter 1|12 pages

The Importance of the First 1,000 Days

An Epidemiological Perspective
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section II|2 pages

What Is Normal Growth?

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section III|2 pages

Nutritional Requirements in the Life Stages

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section IV|2 pages

Endocrinology in the Regulation of Growth

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chapter 7|16 pages

Thyroid Function and Growth

The Mechanisms of Iodine
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section V|2 pages

Adverse Pregnancy and Birth Outcomes (Pathophysiology and Consequences)

chapter 8|14 pages

Neural Tube Defects

Mechanisms of Folate
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section VI|2 pages

Pathophysiology and Nutrition Requirements in Child Malnutrition

chapter 13|16 pages

Acute Malnutrition

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chapter 15|16 pages

Chronic Malnutrition

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section VII|2 pages

Body Composition

section VIII|2 pages

The Gut Microbiome

section IX|2 pages

Effects of Early Life Exposures and Nutrition

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section X|2 pages

Effective Interventions during the First 1,000 Days

section XI|2 pages

Before and Beyond the 1,000 Days

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chapter 29|14 pages

Adolescent Nutrition

A Critical Opportunity for Intervention
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section XII|2 pages

Discovery Research

chapter 30|12 pages

Metabolomics and Proteomics

Methodological Advances to Increase Our Knowledge of Biology during the First 1,000 Days
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