ABSTRACT
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for
Optoelectronics, Huazhong University of Science and Technology, Wuhan, PR China
6.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
6.2 Optical Imaging Techniques of Functional Brain . . . . . . . . . . . . . . . . . . . . . . . . . . 159
6.3 Influence of Acute Hyperglycaemia on CBF and SD in Rat Cortex . . . . . . . . . 164
6.4 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168
Acknowledgment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 174
Disturbances in glycaemia can significantly alter brain functions. Several brain-
mapping techniques have been developed to characterize complex functional topog-
raphy of the brain. This chapter introduces basic principles and instrumentations
of two optical imaging techniques used for investigating cerebral hemodynamics:
intrinsic optical signal imaging and laser speckle imaging. Especially, these two
imaging techniques are used to study influences of acute hyperglycaemia on cerebral
blood flow and spreading depression in rat cerebral cortex.
