ABSTRACT
Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012, Rus-
sia
Valery V. Tuchin
Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012, Rus-
sia,
Institute of Precise Mechanics and Control of RAS, Saratov 410028, Russia
19.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 588
19.2 Spectroscopic Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 589
19.3 Photoacoustic Technique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 596
19.4 Use of Radioactive Labels for Detecting Matter Flux . . . . . . . . . . . . . . . . . . . . . . 598
19.5 Light Scattering Measurements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 600
19.6 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 612
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 613
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 614
In this chapter we have reviewed the main experimental methods, which are widely
used for in vitro and in vivo measurements of glucose diffusion and permeability co-
efficients in human tissues. These methods are based on the spectroscopic and pho-
toacoustic techniques, on the usage of radioactive labels for detecting matter flux,
or on the measurements of temporal changes of the scattering properties of a tissue
caused by refractive index matching including interferometric technique and opti-
cal coherence tomography. The methods provide reliable basis for measurement of
glucose diffusion characteristics in tissues. The obtained results can be used in diag-
nostics and therapy of different diseases related to glucose impact.
