ABSTRACT

This book highlights proteasome structures and how they are related to different aspects of proteasome function. Moreover, the book reports on the functional roles these highly developed proteolytic machines play within the cell. It was a great surprise to the scientific world that proteolysis provides crucial functions in cellular regulation. The

chapter 1|7 pages

Proteasomes: A Historical Retrospective

chapter 2|13 pages

Proteasomes in Prokaryotes

chapter 3|16 pages

Proteasome Crystal Structures

chapter 10|22 pages

The Proteasome Inhibitors and Their Uses

chapter 11|10 pages

Intracellular Localization of Proteasomes

chapter 12|18 pages

Primary Destruction Signals

chapter 13|12 pages

The Ubiquitin System in Yeast

chapter 18|13 pages

p53 and the Proteasome Pathway

chapter 19|17 pages

The Role of the Proteasome in Apoptosis