ABSTRACT
Introduction 523
Hsp: An Overview 524
Hsp70 524
Heat Shock Regulation 525
Medical and Pharmaceutical Interest in Hsp 526
Cosmeceutical Interest in Hsp 527
Inducing Hsp70 527
Supplying Hsp70 527
Effects of Hsp on the Skin: In Vitro and Ex Vivo Studies 528
Thermal Tolerance 528
Hsp and UV Stress 528
Hsp and Aging 529
Hsp and Retinoids 531
Looking Ahead 532
References 533
INTRODUCTION
Through their long evolution, living cells have developed different mechanisms
to counter the increasing stress that they must face. Today, it is well known that
stress directly influences our health and well-being, and affects the functioning of
most of our organs, including our skin. Stress has different origins including
environmental, nutritional, and psychological causes. In recent years, interest
in environmental stresses has increased and has become especially focused on
UV stress, as UV plays a central role in photoaging and skin cancer. Other
important causes of stress in living cells include thermal shock, oxygen free
radicals, chemical substances, as well as inflammatory and infectious states,
among other causes.
