ABSTRACT

This title includes a number of Open Access chapters.Epigenetics refers to DNA and chromatin modifications that play an important role in the regulation of various genomic functions. This important book reviews human and cellular data that underline paradoxical findings with respect to the contribution of heredity and environment to phenotype. The

part |2 pages

PART I: FROM GENES TO EPIGENOMES

chapter 1|20 pages

THE EPIGENETIC PERSPECTIVE

part |2 pages

PART II: DNA METHYLATION

chapter 3|30 pages

PROMOTER HYPERMETHYLATION

chapter 4|40 pages

GENOME-WIDE MAPPING

part |2 pages

PART III: HISTONE MODIFICATIONS

chapter 5|42 pages

GENE SILENCING

chapter 6|36 pages

HISTONE (H1) PHOSPHORYLATION

chapter 7|12 pages

Post-Translational Modifi cations

part |2 pages

PART IV: CHROMATIN MODIFICATIONS

chapter 8|34 pages

CHROMATIN SIGNATURE

chapter 9|24 pages

Bivalent Chromatin Modifi cation

part |2 pages

PART V: THE ROLE OF ENVIRONMENT DURING EVOLUTION

chapter 10|24 pages

ADAPTIVE DIVERGENCE

chapter |7 pages

AUTHOR NOTES