ABSTRACT
Preface . . . . . . . . . . . . . . . . 5 Acknowledgments . . . . . . . 6
CHAPTER 1 Introduction Thomas Mason Assessment of the child with rheumatic disease Approach to children with rheumatic disease Inflammatory versus
non-inflammatory . . . . . . 8 Acute, inflammatory,
articular . . . . . . . . . . . . . . 8 Chronic, inflammatory,
articular . . . . . . . . . . . . . . 8 Chronic, inflammatory,
organ involvement . . . . . 10
CHAPTER 2 Juvenile idiopathic arthritis Egla Rabinovich and Angela Robinson Systemic arthritis . . . . . . . . . 14 Oligoarthritis . . . . . . . . . . . 21 Polyarthritis . . . . . . . . . . . . 28
spondyloarthropathy . . . 38 Juvenile ankylosing
spondylitis . . . . . . . . . . . 42 Juvenile psoriatic
arthritis . . . . . . . . . . . . . 48 Inflammatory bowel
disease-associated arthropathy . . . . . . . . . . 50
Reactive arthropathies Reactive arthritis . . . . . . . . . 54
Post-streptococcal arthropathies Acute rheumatic fever . . . . . 56 Post-streptococcal reactive
arthritis . . . . . . . . . . . . . 58
erythematosus . . . . . . . . 62 Mixed connective tissue
disease . . . . . . . . . . . . . . 76 Neonatal lupus
syndrome . . . . . . . . . . . . 80 Cutaneous lupus
erythematosus . . . . . . . . 82
CHAPTER 5 Idiopathic inflammatory myopathies Floranne Ernste and Ann M Reed Juvenile dermatomyositis . . 88 Juvenile polymyositis . . . . . 101 Postinfectious myositis . . . 103
CHAPTER 6 Vasculitis Robert Sundel Kawasaki disease . . . . . . . . 106 Henoch-Schönlein
pupura . . . . . . . . . . . . . 109 Polyarteritis nodosa . . . . . . 111 ANCA-associated
vasculitides . . . . . . . . . . 114 Takayasu arteritis . . . . . . . 118 Primary angiitis of
the central nervous system . . . . . . . . . . . . . 120
sclerosis . . . . . . . . . . . . 124 Juvenile localized
scleroderma . . . . . . . . . 130
fever . . . . . . . . . . . . . . 140 Cold-induced
autoinflammatory syndrome 1 (CIAS1-pathies) – the cryopyrin-associated periodic fever syndromes . . . . . . . . . . 144
Hyperimmunoglobulinemia D with periodic fever syndrome . . . . . . . . . . . 146
Tumor necrosis factor receptor-associated periodic syndrome . . . . 148
Other monogenic autoinflammatory syndromes
Pyogenic sterile arthritis, pyoderma gangrenosum, and acne syndrome . . . . 150
Early onset sarcoidosis (sporadic granulomatous arthritis), Blau syndrome (familial granulomatous arthritis), and Crohn disease . . . . . . . . . . . . . 150
Autoinflammatory syndromes that are not monogenic/ autoinflammatory diseases with complex genetic traits . . . . . . . . 154
