ABSTRACT
Formulation design, in general, involves chemistry and engineering, thus requiring an understanding of the variety of excipient chemicals and manufacturing techniques. Drug molecules are often poorly water-soluble and are difficult to effectively administer in vivo owing to solubility limitations. Some solubilizing excipients that have been known for a while are finally receiving well-deserved attention with commercial successes such as α-tocopherols and oleic acid. This entry focuses on solubilizing excipients with selected examples of commercially available human pharmaceutical products, and is organized to reflect administration—oral, injectable, and transdermal.
